Study Group B


Purpose of the Study Group B

People at high risk for developing lung cancer are candidates to participate in the Study Group B. Approximately 50 study participants are expected to develop lung cancer during the 4-year study period. Doctors will compare the biomarkers of these study participants to the biomarkers of study participants who do not develop lung cancer. By comparing the biomarkers of the two groups, the study doctors hope to discover specific biomarkers that will help identify which patients are most likely to develop lung cancer.

For more information, click on a topic below:
Who can join the study?
What are participants being asked to do?
How long are people in the study?

Who can join the study?

People are eligible to participate in Group B if they:

  • Are 50 to 79 years old
  • Are a current smoker (smoke at least 10 cigarettes each day) or a former smoker who quit no more than 20 years ago and has at least 20 “pack years” of smoking. Pack years = number of packs smoked per day x number of years smoked
  • Have emphysema or chronic bronchitis, which are two forms of chronic obstructive pulmonary disease (COPD), or have at least one firstdegree relative (parent, brother or sister, child) who has been diagnosed with lung cancer
  • Are willing to undergo fiber optic bronchoscopy
  • Are able to tolerate the biospecimen collections required for the study

What are participants being asked to do?
People who take part in this study will:

  • Fill out a lung questionnaire
  • Do the following once each year for 3 years:
    • Provide different types of biological samples (called “biospecimens”), including sputum, blood, urine, cells, and tissue. All biospecimens will be stored for future research
    • Provide cells from your nose and mouth by brushings from your nose and scrapings from your mouth
    • Have a bronchoscopy the first and third year you are in the study. A bronchoscopy is a test to view the lungs using a flexible device (called a “bronchoscope”). During this procedure, brushings of cells and biopsy samples are collected
  • Do the following once each year for 4 years:
    • Have a physical examination and diagnostic work-up
    • Do a pulmonary function test, which measures your ability to breathe when you blow into a special device
    • Have a CT scan, which is an imaging study to evaluate the health of your lungs

How long are people in the study?
People are in the study for about 4 years. Study participants who are diagnosed with lung cancer during the study will not continue to have any further study-related procedures. This study is expected to end after all patients have completed the follow-up visits and all information has been collected