DECAMP STUDY 1 PARTICIPATION

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General Information About Participating in DECAMP Study 1

Study volunteers (or "participants") joining this trial will be one of the 500 patients with a diagnosis of an indeterminate pulmonary nodule who volunteer to enroll in the trial. Study participants will be enrolled at 7 Veterans Administration hospitals, 4 designated military treatment facilities, and 1 academic hospital (see Locations). 

The photo to the right shows what the CT technologist sees during a CT scan exam.

The technologist obtains the images of the lungs using predefined specifications. The images are then interpreted (or "read") by a radiologist. 


For more information click on the topics below:
Who can join DECAMP Study 1?
What are participants being asked to do?
How long will participants be in the study?

Who can join DECAMP Study 1
People are eligible for this study if they:

  • Are age 50 years or older
  • Have an initial diagnosis (within the last 3 months) of an indeterminate pulmonary module
  • Are a current or former smoker with a smoking history of at least 30 pack years
  • Are willing to undergo fiberoptic bronchoscopy
  • Are able to comply with standard-of-care follow-up visits, including clinical examinations, diagnostic work-ups, and imaging tests, for a minimum of 2 years

People are not eligible to take part in this study if they:

  • Have a history or previous diagnosis of lung cancer
  • Have a diagnosis of a type of pulmonary nodules called “ground glass” nodules on your chest computed tomography (CT) scans
  • Are not recommended to have the procedures required to collect the study biospecimens
  • Have allergies to any local anesthetic that may be used to obtains biospecimens in the study

What are participants being asked to do?
People joining the trial will be asked to:

 

  • Complete a lung questionnaire that includes questions about their background, lifestyle, health history, smoking history, etc.
  • Provide different types of biological samples (called “biospecimens”), including sputum, blood, urine, cells, and tissue; All biospecimens will be stored for future research
  • Provide cells from the nose and mouth by brushings from your nose and scrapings from your mouth
  • Undergo a bronchoscopy, which uses a bronchoscope to see the inside of the lungs and obtains a biopsy sample (small piece of the nodule tissue) in order to help in the diagnosis of lung disease
  • Undergo a pulmonary function test in which you blow in a device to measure the ability to breathe
  • Return for standard-of-care clinical examinations and diagnostic work-ups to check on your nodule
  • Return to undergo surgery, if necessary and prescribed by the doctor, during which tumor tissue will be removed for the study

How long will study participants be in the study?
For a period of 2 years, study participants will visit their doctor regularly for clinical examination and have follow-up imaging tests until doctors determine if your pulmonary nodule is benign (noncancerous) or malignant (cancerous). At that point, participants will receive the standard of care treatment as prescribed by their doctor. The trial is expected to end after all patients have completed the follow-up visits and all information has been collected.